Ivermectin FDA Link

A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.

Also Known As:

Mectizan; Stromectol; Eqvalan; Ivomec; MK-933; MK 933; MK933

Pharmalogical Action Categories:

Antiparasitic Agents
Insecticides

Organic Chemicals: 133
- Lactones: 1549
  - Polyketides: 231
    - Macrolides: 4391
      - Ivermectin: 3421

J Pertusa Selected Research

J Pertusa Research Topics

Disease

Drug/Important Bio-Agent (IBA)